Liver Pain

Learn the details about liver pain.


Mononucleosis is a viral disease generally brought on by the Epstein-Barr Virus (EBV). It goes by a variety of other names, such as infectious mononucleosis, mono, glandular fever, Pfeiffer's disease, and others. This condition is one of the possible medical causes of liver pain or tenderness.


Some of the possible symptoms of mononucleosis may include the following:

Erythema multiforme
Hepatomegaly (liver enlargement)
Jaundice (yellowing of the skin and/or certain membranes)
Lymphadenopathy (swollen lymph nodes)
Pancytopenia (decreased levels of all kinds of blood cells)
Pharyngeal inflammation
Sore throat
Splenic hemorrhage
Splenic rupture
Splenomegaly (enlarged spleen)
Thrombocytopenia (decreased platelet count)
Weight loss


Infectious mononucleosis is generally caused by the Epstein-Barr virus. Another form of mono is caused by the cytomegalovirus. There may be other potential causes, as well.


A common method of diagnosis is checking whether 50 percent lymphocytes and 10 percent atypical lymphocytes, or greater in either case, are present. This is checked along with looking for symptoms of pharyngitis, swollen lymph nodes, and fever. Blood tests can be used for confirmation when a diagnosis is made this way. Some other diseases mimic mononucleosis in particular ways, so a differential diagnosis, using the process of elimination, may be made to rule out some of the other possible conditions. In some instances of testing, another condition may actually be confirmed.


A case of mononucleosis often runs its course, and does not need any treatment for affecting the condition. However, treatment may be given for the symptoms. Rest is generally prescribed during the acute stage of the disease. Even after that, rigorous physical activity should be avoided for at least one month, in an attempt to avoid splenic rupture.

Return home to read about other potential causes of liver pain.